The "resin-capture-release" hybrid technique

A merger between solid- and solution-phase synthesis

authored by

Andreas Kirschning, Holger Monenschein, Rüdiger Wittenberg

Abstract

A polymer-assisted organic synthesis that combines the concept of solid-phase synthesis with the idea of polymer-supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the "resin-capture-release" methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer-bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.

Organisation(s)

Institute of Organic Chemistry

External Organisation(s)

Clausthal University of Technology

Type

Article

Journal

Chemistry - A European Journal

Volume

6

Pages

4445-4450

No. of pages

6

ISSN

0947-6539

Publication date

27.11.2000

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Catalysis, Organic Chemistry

Electronic version(s)

https://doi.org/10.1002/1521-3765(20001215)6:24<4445::AID-CHEM4445>3.0.CO;2-W (Access: Unknown)