New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling

authored by

Burkhon Elmuradov, Rasul Okmanov, Bakhromjon Juraev, Gerald Dräger, Holger Butenschön

Abstract

A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.

Organisation(s)

Institute of Organic Chemistry

External Organisation(s)

Uzbekistan Academy of Sciences

Type

Article

Journal

CHEMISTRYOPEN

Volume

13

No. of pages

15

ISSN

2191-1363

Publication date

08.12.2024

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

General Chemistry

Electronic version(s)

https://doi.org/10.1002/open.202400197 (Access: Open)