New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling

verfasst von

Burkhon Elmuradov, Rasul Okmanov, Bakhromjon Juraev, Gerald Dräger, Holger Butenschön

Abstract

A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.

Organisationseinheit(en)

Institut für Organische Chemie

Externe Organisation(en)

Uzbekistan Academy of Sciences

Typ

Artikel

Journal

CHEMISTRYOPEN

Band

13

Anzahl der Seiten

15

ISSN

2191-1363

Publikationsdatum

08.12.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Allgemeine Chemie

Elektronische Version(en)

https://doi.org/10.1002/open.202400197 (Zugang: Offen)