Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model

authored by: Meike Gierig, Pierfrancesco Gaziano, Peter Wriggers, Michele Marino
Abstract: This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.
Organisation(s): Institute of Continuum Mechanics
External Organisation(s): Tor Vergata University of Rome
Type: Article
Journal: Journal of biomechanics
Volume: 166
No. of pages: 13
ISSN: 0021-9290
Publication date: 03.2024
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Biophysics, Biomedical Engineering, Orthopedics and Sports Medicine, Rehabilitation
Electronic version(s): https://doi.org/10.1016/j.jbiomech.2024.112058 (Access: Open)

BibTeX

@article{f800303903f2478bab497fb21c8cc612,
title = "Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model",
abstract = "This work presents the application of a chemo-mechano-biological constitutive model of soft tissues for describing tissue inflammatory response to damage in collagen constituents. The material model is implemented into a nonlinear finite element formulation to follow up a coronary standard balloon angioplasty for one year. Numerical results, compared with available in vivo clinical data, show that the model reproduces the temporal dynamics of vessel remodeling associated with subintimal damage. Such dynamics are bimodular, being characterized by an early tissue resorption and lumen enlargement, followed by late tissue growth and vessel constriction. Applicability of the modeling framework in retrospective studies is demonstrated, and future extension towards prospective applications is discussed.",
keywords = "Balloon angioplasty, Chemo-mechano-biological model, In silico medicine, Tissue inflammatory response, Vessel remodeling",
author = "Meike Gierig and Pierfrancesco Gaziano and Peter Wriggers and Michele Marino",
note = "Funding Information: MM and PG gratefully acknowledge funding from Regione Lazio (POR FESR LAZIO 2014; Progetti di Gruppi di Ricerca 2020; project: BIOPMEAT, n. A0375-2020-36756) and support from the Italian National Group for Mathematical Physics GNFM-INdAM. PW gratefully acknowledges the support by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - SFB/TRR-298-SIIRI - Project-ID 426335750.",
year = "2024",
month = mar,
doi = "10.1016/j.jbiomech.2024.112058",
language = "English",
volume = "166",
journal = "Journal of biomechanics",
issn = "0021-9290",
publisher = "Elsevier Ltd.",
}