Remarkable hydrolysis of phosphodiester by neutral lanthanide(III) DO3A complexes

authored by
Markus Kalesse, Andrea Loos
Abstract

The hydrolysis of the 4-nitrophenyl phosphate ester of propylene glycol (HPNP) is catalyzed by neutral lanthanide(III) DO3A complexes. Hydrolysis experiments with complexes of modified ligands where the metal complex was positively charged did not yield in a significant increase of the rate constant.

Organisation(s)
Institute of Organic Chemistry
Type
Article
Journal
Bioorganic and Medicinal Chemistry Letters
Volume
6
Pages
2063-2068
No. of pages
6
ISSN
0960-894X
Publication date
03.09.1996
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Biochemistry, Molecular Medicine, Molecular Biology, Pharmaceutical Science, Drug Discovery, Clinical Biochemistry, Organic Chemistry
Electronic version(s)
https://doi.org/10.1016/0960-894X(96)00386-1 (Access: Unknown)