Synthesis of the C1-C9 segment of epothilons

authored by

Eckhard Claus, Axel Pahl, Peter G. Jones, Hartmut M. Meyer, Markus Kalesse

Abstract

The C1-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.

External Organisation(s)

Technische Universität Braunschweig

Type

Article

Journal

Tetrahedron letters

Volume

38

Pages

1359-1362

No. of pages

4

ISSN

0040-4039

Publication date

24.02.1997

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Biochemistry, Drug Discovery, Organic Chemistry

Electronic version(s)

https://doi.org/10.1016/S0040-4039(96)02493-8 (Access: Unknown)