Modifications of the closure principle for analyzing toxicological studies
- authored by
- Ludwig A. Hothorn
- Abstract
A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held on March, 25-27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper proposes a simple closure test for dose-response relationships under real data conditions. This approach takes into account deviation from variance homogeneity and monotonicity assumptions. Moreover, this approach can be easily adapted for “any” kind of two-sample tests, for example, nonparametric, dichotomous, censored, and so forth. Power was compared by a simulation study for selected conditions.
- Organisation(s)
-
Department of Biostatistics
- Type
- Article
- Journal
- Therapeutic Innovation & Regulatory Science
- Volume
- 31
- Pages
- 403-412
- No. of pages
- 10
- ISSN
- 2168-4790
- Publication date
- 30.12.1997
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Public Health, Environmental and Occupational Health, Pharmacology (medical)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Electronic version(s)
-
https://doi.org/10.1177/009286159703100211 (Access:
Closed)
https://doi.org/10.15488/3022 (Access: Open)
