An efficient synthesis of radicinin analogues
- authored by
- Marcus Eh, Dietmar Schomburg, Kathrin Schicht, Markus Kalesse
- Abstract
We describe herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it depresses the heart ventricular strip and histamine contraction. The key reaction to establish the radicinin skeleton is the reduction of the pseudo C2 symmetrical precursor 11 with the aid of TiCl4 and LiBH4.
- Organisation(s)
-
Institute of Organic Chemistry
- External Organisation(s)
-
Helmholtz Centre for Infection Research (HZI)
- Type
- Article
- Journal
- TETRAHEDRON
- Volume
- 51
- Pages
- 8983-8992
- No. of pages
- 10
- ISSN
- 0040-4020
- Publication date
- 14.08.1995
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biochemistry, Drug Discovery, Organic Chemistry
- Electronic version(s)
-
https://doi.org/10.1016/0040-4020(95)00491-P (Access:
Closed)
