Influence of a magnesium-fluoride coating of magnesium-based implants (MgCa0.8) on degradation in a rabbit model

authored by

Martina Thomann, Christian Krause, Nina Angrisani, Dirk Bormann, Thomas Hassel, Henning Windhagen, Andrea Meyer-Lindenberg

Abstract

MgCa0.8 cylinders (2.5 × 25 mm²) were coated with a magnesium-fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro-computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX-analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders.

Organisation(s)

Institute of Materials Science

External Organisation(s)

University of Veterinary Medicine of Hannover, Foundation
Hannover Medical School (MHH)

Type

Article

Journal

Journal of Biomedical Materials Research - Part A

Volume

93

Pages

1609-1619

No. of pages

11

ISSN

1549-3296

Publication date

15.06.2010

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Ceramics and Composites, Biomaterials, Biomedical Engineering, Metals and Alloys

Electronic version(s)

https://doi.org/10.1002/jbm.a.32639 (Access: Closed)