Influence of a magnesium-fluoride coating of magnesium-based implants (MgCa0.8) on degradation in a rabbit model

verfasst von

Martina Thomann, Christian Krause, Nina Angrisani, Dirk Bormann, Thomas Hassel, Henning Windhagen, Andrea Meyer-Lindenberg

Abstract

MgCa0.8 cylinders (2.5 × 25 mm²) were coated with a magnesium-fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro-computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX-analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders.

Organisationseinheit(en)

Institut für Werkstoffkunde

Externe Organisation(en)

Stiftung Tierärztliche Hochschule Hannover
Medizinische Hochschule Hannover (MHH)

Typ

Artikel

Journal

Journal of Biomedical Materials Research - Part A

Band

93

Seiten

1609-1619

Anzahl der Seiten

11

ISSN

1549-3296

Publikationsdatum

15.06.2010

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Keramische und Verbundwerkstoffe, Biomaterialien, Biomedizintechnik, Metalle und Legierungen

Elektronische Version(en)

https://doi.org/10.1002/jbm.a.32639 (Zugang: Geschlossen)