Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis-results of preliminary studies

authored by: S. Biedron, J. F.R. Ilgner, E. Fadeeva, B. Chichkov, A. Prescher, M. Bovi, M. Westhofen
Abstract: The objective of this study was to optimize titanium surfaces by means of Ti:Sapphire femtosecond laser to improve the attachment of human cartilage cells on titanium prosthesis in middle ear surgery. The application of microstructures on titanium samples was evaluated and the influence of these microstructures on human auricular chondrocytes was studied in-vitro. After establishing the ear chondrocyte cell culture, cells were seeded on titanium platelets with selected microstructure patterns. Whereas the phenotype of cells seeded on unstructured titanium was similar to cells grown on standard tissue culture surfaces, the morphology of chondrocytes grown on structured titanium samples was influenced by the pattern. For future titanium middle ear prosthesis structural optimizations will be developed to promote chondrocyte growth and adhesion while impeding fibrocyte proliferation to avoid scarring on implant interfaces.
External Organisation(s): RWTH Aachen University
Laser Zentrum Hannover e.V. (LZH)
Type: Conference contribution
Publication date: 17.07.2009
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Instrumentation, Atomic and Molecular Physics, and Optics
Electronic version(s): https://doi.org/DOI:10.1117/12.831883 (Access: Closed)

BibTeX

@inproceedings{4c6acaad64384cefb1ee6ce1d9baee53,
title = "Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis-results of preliminary studies",
abstract = "The objective of this study was to optimize titanium surfaces by means of Ti:Sapphire femtosecond laser to improve the attachment of human cartilage cells on titanium prosthesis in middle ear surgery. The application of microstructures on titanium samples was evaluated and the influence of these microstructures on human auricular chondrocytes was studied in-vitro. After establishing the ear chondrocyte cell culture, cells were seeded on titanium platelets with selected microstructure patterns. Whereas the phenotype of cells seeded on unstructured titanium was similar to cells grown on standard tissue culture surfaces, the morphology of chondrocytes grown on structured titanium samples was influenced by the pattern. For future titanium middle ear prosthesis structural optimizations will be developed to promote chondrocyte growth and adhesion while impeding fibrocyte proliferation to avoid scarring on implant interfaces.",
keywords = "Biomaterials, Cell culture, Chondrocyte, Contact guidance, Ear cartilage, Femtosecond laser, Microstructures, Titanium",
author = "S. Biedron and Ilgner, {J. F.R.} and E. Fadeeva and B. Chichkov and A. Prescher and M. Bovi and M. Westhofen",
year = "2009",
month = jul,
day = "17",
doi = "DOI:10.1117/12.831883",
language = "English",
isbn = "9780819476432",
series = "Optics InfoBase Conference Papers",
publisher = "OSA - The Optical Society",
booktitle = "European Conference on Biomedical Optics, ECBO 2009",
address = "United States",
note = "European Conference on Biomedical Optics, ECBO 2009 ; Conference date: 14-06-2009 Through 18-06-2009",
}