Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase
- authored by
- Elizabeth J. Skellam, Deirdre Hurley, Jack Davison, Colin M. Lazarus, Thomas J. Simpson, Russell J. Cox
- Abstract
Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production.
- External Organisation(s)
-
University of Bristol
- Type
- Article
- Journal
- Molecular BioSystems
- Volume
- 6
- Pages
- 680-682
- No. of pages
- 3
- ISSN
- 1742-206X
- Publication date
- 26.03.2010
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Biotechnology, Molecular Biology
- Electronic version(s)
-
https://doi.org/10.1039/b923990a (Access:
Unknown)
