Bio-field-effect Transistors for Process Control in Biotechnology

authored by

U. Brand, B. Reinhardt, F. Rüther, T. Scheper, K. Schügerl

Abstract

The application of enzyme-modified field-effect transistors (BioFETs) in biotechnological process control is presented. Penicillin, glucose and urea are detected with these devices in cultivation media and on-line in biotechnological processes. In these applications, the BioFETs are used as detectors in flow injection analysis (FIA) systems. Special flow cells with a small volume, constructed for this purpose, guarantee an optimum sample transport to the sensor. Therefore, 15-20 determinations per hour can be performed. The BioFET/FIA system gives good results for the on-line monitoring of glucose and urea during cultivations of S. cerevisiae and E. coli in different types of bioreactors.

Organisation(s)

Institute of Technical Chemistry

Type

Article

Journal

Sensors and Actuators: B. Chemical

Volume

4

Pages

315-318

No. of pages

4

ISSN

0925-4005

Publication date

06.1991

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials, Instrumentation, Condensed Matter Physics, Surfaces, Coatings and Films, Metals and Alloys, Electrical and Electronic Engineering, Materials Chemistry

Electronic version(s)

https://doi.org/10.1016/0925-4005(91)80129-8 (Access: Unknown)