Synthesis of 4-amino 3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics
- authored by
- Andreas Kirschning, Philippe Bergon, Jeh Jeng Wang, Steven Breazeale, Heinz G. Floss
- Abstract
The synthesis of 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-d-glucose in 14 steps in 10-12% overall yield.
- External Organisation(s)
-
University of Washington
- Type
- Article
- Journal
- Carbohydrate Research
- Volume
- 256
- Pages
- 245-256
- No. of pages
- 12
- ISSN
- 0008-6215
- Publication date
- 01.04.1994
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- Analytical Chemistry, Biochemistry, Organic Chemistry
- Electronic version(s)
-
https://doi.org/10.1016/0008-6215(94)84211-6 (Access:
Unknown)
