Asymptotic simultaneous confidence intervals for many-to-one comparisons of binary proportions in randomized clinical trials

verfasst von

Frank Schaarschmidt, Egbert Biesheuvel, Ludwig A. Hothorn

Abstract

The simultaneous comparison of proportions of success between many treatments and one control group is a common problem in randomized clinical trials or toxicity studies. In this article, three recently recommended asymptotic confidence interval approaches for the difference of proportions are adjusted for multiplicity, taking the correlation into account. The coverage probability of the resulting interval methods is compared in a simulation study using parameter settings relevant for clinical trials. For moderate to small sample sizes, a method adding two successes and two failures can be recommended. The usage of the proposed methods is illustrated by two examples; an R package is available.

Organisationseinheit(en)

Abteilung Biostatistik

Externe Organisation(en)

Organon Inc.

Typ

Artikel

Journal

Journal of Biopharmaceutical Statistics

Band

19

Seiten

292-310

Anzahl der Seiten

19

ISSN

1054-3406

Publikationsdatum

2009

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Statistik und Wahrscheinlichkeit, Pharmakologie, Pharmakologie (medizinische)

Elektronische Version(en)

https://doi.org/10.1080/10543400802622501 (Zugang: Geschlossen)