High-Resolution Drift Tube Ion Mobility Spectrometer with Ultra-Fast Polarity Switching

verfasst von: Moritz Hitzemann, Ansgar T. Kirk, Martin Lippmann, Alexander Nitschke, Olaf Burckhardt, Jonas Winkelholz, Stefan Zimmermann
Abstract: Besides safety and security applications, ion mobility spectrometry (IMS) is increasingly used in other fields such as medicine, environmental monitoring and food quality analysis. However, some applications require gas chromatographic separation before analysis by IMS. Furthermore, different compounds in the sample may form positive or negative ions during ionization and therefore simultaneous detection of both ion polarities is highly beneficial to avoid two chromatographic runs of the same sample. This can be achieved by ultra-fast polarity switching of a single drift tube IMS, allowing for quasi-simultaneous detection of both ion polarities. By using a ramped aperture voltage during the switching process, we overcome the issue of excessive displacement currents at the detector during polarity switching, which usually lead to overdriving the output signal of the high-gain transimpedance amplifier. Furthermore, mechanical aperture grid oscillations caused by polarity switching were also reduced through the ramped aperture voltage. This enables a polarity switching time of only 7 ms at a drift voltage of 8 kV and a drift length of 103 mm, leading to a high resolving power of R_P = 117. Requiring 50 ms to acquire a pair of positive and negative spectrum, the IMS achieves an acquisition rate of 20 Hz. It reaches limits of detection of 20 ppt_v for dimethyl methylphosphonate and 40 ppt_v for methyl salicylate. For demonstration, different hop varieties were investigated and could be clearly differentiated by considering both, the positive and negative spectra.
Organisationseinheit(en): Institut für Grundlagen der Elektrotechnik und Messtechnik
Typ: Artikel
Journal: Analytical chemistry
Band: 96
Seiten: 14630-14638
Anzahl der Seiten: 9
ISSN: 0003-2700
Publikationsdatum: 10.09.2024
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Analytische Chemie
Elektronische Version(en): https://doi.org/10.1021/acs.analchem.4c03296 (Zugang: Offen)

BibTeX

@article{d68aa6084e864a7283d3b270d3ca1a04,
title = "High-Resolution Drift Tube Ion Mobility Spectrometer with Ultra-Fast Polarity Switching",
abstract = "Besides safety and security applications, ion mobility spectrometry (IMS) is increasingly used in other fields such as medicine, environmental monitoring and food quality analysis. However, some applications require gas chromatographic separation before analysis by IMS. Furthermore, different compounds in the sample may form positive or negative ions during ionization and therefore simultaneous detection of both ion polarities is highly beneficial to avoid two chromatographic runs of the same sample. This can be achieved by ultra-fast polarity switching of a single drift tube IMS, allowing for quasi-simultaneous detection of both ion polarities. By using a ramped aperture voltage during the switching process, we overcome the issue of excessive displacement currents at the detector during polarity switching, which usually lead to overdriving the output signal of the high-gain transimpedance amplifier. Furthermore, mechanical aperture grid oscillations caused by polarity switching were also reduced through the ramped aperture voltage. This enables a polarity switching time of only 7 ms at a drift voltage of 8 kV and a drift length of 103 mm, leading to a high resolving power of RP = 117. Requiring 50 ms to acquire a pair of positive and negative spectrum, the IMS achieves an acquisition rate of 20 Hz. It reaches limits of detection of 20 pptv for dimethyl methylphosphonate and 40 pptv for methyl salicylate. For demonstration, different hop varieties were investigated and could be clearly differentiated by considering both, the positive and negative spectra.",
author = "Moritz Hitzemann and Kirk, {Ansgar T.} and Martin Lippmann and Alexander Nitschke and Olaf Burckhardt and Jonas Winkelholz and Stefan Zimmermann",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Published by American Chemical Society.",
year = "2024",
month = sep,
day = "10",
doi = "10.1021/acs.analchem.4c03296",
language = "English",
volume = "96",
pages = "14630--14638",
journal = "Analytical chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "36",
}