Experimental middle ear surgery in rabbits

A new approach for reconstructing the ossicular chain

verfasst von: M. Stieve, H. J. Hedrich, R. D. Battmer, P. Behrens, P. Müller, Th Lenarz
Abstract: This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO₂) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).
Organisationseinheit(en): Institut für Anorganische Chemie
Externe Organisation(en): Medizinische Hochschule Hannover (MHH)
Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
Typ: Artikel
Journal: Laboratory animals
Band: 43
Seiten: 198-204
Anzahl der Seiten: 7
ISSN: 0023-6772
Publikationsdatum: 01.04.2009
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Nutztierwissenschaften und Zoologie, Veterinärmedizin (insg.)
Elektronische Version(en): https://doi.org/10.1258/la.2008.007152 (Zugang: Offen)

BibTeX

@article{83623375ea164358a6e340b67448f3c5,
title = "Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain",
abstract = "This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).",
keywords = "Brain response audiometry, Experimental middle ear surgery, Ossicular chain prostheses, Rabbit",
author = "M. Stieve and Hedrich, {H. J.} and Battmer, {R. D.} and P. Behrens and P. M{\"u}ller and Th Lenarz",
year = "2009",
month = apr,
day = "1",
doi = "10.1258/la.2008.007152",
language = "English",
volume = "43",
pages = "198--204",
journal = "Laboratory animals",
issn = "0023-6772",
publisher = "SAGE Publications Ltd",
number = "2",
}