Hemodynamical Evaluation of a New Surgically Implanted Pulsatile Right Ventricular Assist Device Driven by a Conventional Intra-Aortic Balloon Pump Console

verfasst von: Sara Knigge, Günes Dogan, Ezin Deniz, Youseph Ismail, Jörg Optenhöfel, Liam Schana, Ali S. Merzah, Jasmin S. Hanke, Issam Ismail, Oren Malchin, Marcelo Bastos, Aron F. Popov, Alexander Weymann, Arjang Ruhparwar, Bastian Schmack, Jan D. Schmitto
Abstract: Severe right heart failure, often overlooked and challenging to manage, has prompted a growing interest in innovative approaches to provide functional support. This study uses experimentation in large porcine models to introduce a novel prototype of a pulsatile mechanical circulatory support device and document its effects when deployed as a right ventricular assist device (RVAD). The pulsatile ventricular assist platform (pVAP), featuring a membrane pump driven by an intra-aortic balloon pump console, actively generates pulsatile flow to propel right ventricular blood into the pulmonary artery. This novel prototype demonstrates promising potential in addressing the challenges of right heart failure management. After preliminary in vitro assessments, the pVAP was tested on seven porcine models in a healthy state and after the induction of right ventricular failure. During the procedure, a set of standard (ie, standard-of-care) hemodynamic measurements was obtained. Additionally, invasive pressure-volume loop analysis was employed to examine left ventricular hemodynamics. Results indicated that activation of the pVAP during right ventricular failure significantly improved systemic hemodynamics and enhanced left ventricular function. This study sheds light on the potential of the pVAP in managing right heart failure.
Organisationseinheit(en): Institut für Mehrphasenprozesse
Externe Organisation(en): Medizinische Hochschule Hannover (MHH)
PulseCath BV
Erasmus University Rotterdam
Typ: Artikel
Journal: ASAIO journal
Band: 70
Seiten: 734-740
Anzahl der Seiten: 7
ISSN: 1058-2916
Publikationsdatum: 09.2024
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Biophysik, Bioengineering, Biomaterialien, Biomedizintechnik
Elektronische Version(en): https://doi.org/10.1097/MAT.0000000000002197 (Zugang: Geschlossen)

BibTeX

@article{78f63af7249441f4a999edd2e3bdcdda,
title = "Hemodynamical Evaluation of a New Surgically Implanted Pulsatile Right Ventricular Assist Device Driven by a Conventional Intra-Aortic Balloon Pump Console",
abstract = "Severe right heart failure, often overlooked and challenging to manage, has prompted a growing interest in innovative approaches to provide functional support. This study uses experimentation in large porcine models to introduce a novel prototype of a pulsatile mechanical circulatory support device and document its effects when deployed as a right ventricular assist device (RVAD). The pulsatile ventricular assist platform (pVAP), featuring a membrane pump driven by an intra-aortic balloon pump console, actively generates pulsatile flow to propel right ventricular blood into the pulmonary artery. This novel prototype demonstrates promising potential in addressing the challenges of right heart failure management. After preliminary in vitro assessments, the pVAP was tested on seven porcine models in a healthy state and after the induction of right ventricular failure. During the procedure, a set of standard (ie, standard-of-care) hemodynamic measurements was obtained. Additionally, invasive pressure-volume loop analysis was employed to examine left ventricular hemodynamics. Results indicated that activation of the pVAP during right ventricular failure significantly improved systemic hemodynamics and enhanced left ventricular function. This study sheds light on the potential of the pVAP in managing right heart failure.",
keywords = "paracorporal pulsatile pump, percutaneous RVAD, right heart failure, right ventricular assist device",
author = "Sara Knigge and G{\"u}nes Dogan and Ezin Deniz and Youseph Ismail and J{\"o}rg Optenh{\"o}fel and Liam Schana and Merzah, {Ali S.} and Hanke, {Jasmin S.} and Issam Ismail and Oren Malchin and Marcelo Bastos and Popov, {Aron F.} and Alexander Weymann and Arjang Ruhparwar and Bastian Schmack and Schmitto, {Jan D.}",
note = "Publisher Copyright: Copyright {\textcopyright} ASAIO 2024.",
year = "2024",
month = sep,
doi = "10.1097/MAT.0000000000002197",
language = "English",
volume = "70",
pages = "734--740",
journal = "ASAIO journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "9",
}