Modelling of E. Coli fermentations: comparison of multicompartment and variable structure models

verfasst von

B. Tartakovsky, M. Sheintuch, J. M. Hilmer, T. Scheper

Abstract

Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.

Organisationseinheit(en)

Institut für Technische Chemie

Externe Organisation(en)

Technion-Israel Institute of Technology

Typ

Artikel

Journal

Bioprocess Engineering

Band

16

Seiten

323-329

Anzahl der Seiten

7

ISSN

0178-515X

Publikationsdatum

05.1997

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Biotechnologie, Angewandte Mikrobiologie und Biotechnologie

Elektronische Version(en)

https://doi.org/10.1007/PL00008947 (Zugang: Unbekannt)