Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth

verfasst von: Denver Linklater, Yulia Karlagina, Karolinne Martins de Sousa, Daniel E. Heath, Maxim Radaev, Boris N. Chichkov, Galina V. Romanova, Vadim P. Veiko, Elena P. Ivanova
Abstract: Implant surface topography plays an important role in determining cell responses, including attachment, proliferation, migration, and differentiation. With rapid developments in micro-and nano-fabrication methods, precisely controlled patterns can be generated on implant surfaces. Osteon-mimetic structures are of great interest as new surface designs on bone implants for creating optimal conditions for bone tissue growth. In this work, we used a laser ablation technique to create a biomimetic relief on Ti-6Al-4 V supports. The osteon-mimetic reliefs exhibited patterns of concentric lamellae-like rings of different width and periodicity. A distinctive feature of these reliefs is the presence of a highly porous nanocoating of titanium oxides, formed as a result of reverse deposition from the vapor-gas phase during ablation. Our investigation of the response of human mesenchymal stem cells revealed that the osteon-mimetic microrelief topography significantly influenced their adhesion, proliferation, and polarization. The presence of the nanocoating further impacted the number and localization of their focal adhesions. The outcomes of this work demonstrate an innovative direction towards the design of osteon-mimetic topographies on implantable materials. This work also holds the potential to identify optimal combinations of microrelief and nanocoating parameters to elicit specific cellular responses.
Organisationseinheit(en): Institut für Quantenoptik
Externe Organisation(en): University of Melbourne
Royal Melbourne Institute of Technology University
St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO)
Typ: Artikel
Journal: Surfaces and Interfaces
Band: 56
Anzahl der Seiten: 13
ISSN: 2468-0230
Publikationsdatum: 01.01.2025
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Oberflächen, Beschichtungen und Folien
Elektronische Version(en): https://doi.org/10.1016/j.surfin.2024.105503 (Zugang: Offen)

BibTeX

@article{2b1796e2018d401bb8ddb1ddea4d97e7,
title = "Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth",
abstract = "Implant surface topography plays an important role in determining cell responses, including attachment, proliferation, migration, and differentiation. With rapid developments in micro-and nano-fabrication methods, precisely controlled patterns can be generated on implant surfaces. Osteon-mimetic structures are of great interest as new surface designs on bone implants for creating optimal conditions for bone tissue growth. In this work, we used a laser ablation technique to create a biomimetic relief on Ti-6Al-4 V supports. The osteon-mimetic reliefs exhibited patterns of concentric lamellae-like rings of different width and periodicity. A distinctive feature of these reliefs is the presence of a highly porous nanocoating of titanium oxides, formed as a result of reverse deposition from the vapor-gas phase during ablation. Our investigation of the response of human mesenchymal stem cells revealed that the osteon-mimetic microrelief topography significantly influenced their adhesion, proliferation, and polarization. The presence of the nanocoating further impacted the number and localization of their focal adhesions. The outcomes of this work demonstrate an innovative direction towards the design of osteon-mimetic topographies on implantable materials. This work also holds the potential to identify optimal combinations of microrelief and nanocoating parameters to elicit specific cellular responses.",
keywords = "Biomimetic, Osteon, Stem cells, Titanium",
author = "Denver Linklater and Yulia Karlagina and {de Sousa}, {Karolinne Martins} and Heath, {Daniel E.} and Maxim Radaev and Chichkov, {Boris N.} and Romanova, {Galina V.} and Veiko, {Vadim P.} and Ivanova, {Elena P.}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2025",
month = jan,
day = "1",
doi = "10.1016/j.surfin.2024.105503",
language = "English",
volume = "56",
journal = "Surfaces and Interfaces",
issn = "2468-0230",
publisher = "Elsevier BV",
}